2022 AD. The sequel to "EARTH DEFENSE FORCE 5" depicts the battle between the EDF and alien life forms that have suddenly attacked the Earth. Players take on the role of an EDF soldier in this third-person shooter in which they must destroy a large number of giant enemies.

The year is 2024 AD. Mankind has won the long battle against the unknown invaders. The enemy Primers are now gone and peace has returned to Mother Earth. However, the population has shrunk to 10℅ and the world was on the verge of collapse. The survivors fought against the remaining threats while trying their best to continue their recovery. Three years passed in the year 2027. In a new world without hope, the time has come to once again resist the fate of the Earth.

The identity of the invader that has long tormented Earth is finally revealed. A chain of deep despair that strikes in a devastated world for the first time in the series...But your presence as a soldier of the EDF will lead humanity to the greatest joy. Now you must face it with courage and wisdom.